Claim: When used responsibly, marijuana has a beneficial effect on health and overall wellbeing.
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Published: 10 September 2012
This study found a 2-fold increased risk in testicular germ cell tumors in males associated with ever using marijuana.
"The current results warrant mechanistic studies of marijuana's effect on the endocannabinoid system and testicular germ cell tumor risk and caution that recreational and therapeutic use of cannabinoids by young men may confer malignant potential to testicular germ cells."
This study found a 2-fold increased risk in testicular germ cell tumors in males associated with ever using marijuana.
"The current results warrant mechanistic studies of marijuana's effect on the endocannabinoid system and testicular germ cell tumor risk and caution that recreational and therapeutic use of cannabinoids by young men may confer malignant potential to testicular germ cells."
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The endocannabinoid system is a natural part of human health and neurological function. Cannabinoids, and Terpenes, are the main driver of the effects of marijuana. Endocannabinoids are cannabinoids that are created inside the body. Knowing the effects of different cannabinoids is a subject that needs a lot more research. Using cannabis with as much knowledge as we have available, does allow for someone to target specific effects, and can be used to with many beneficial effects. Including release of muscle tension, regulation of the digestive system, or hormonal regulation.
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The associations between marijuana use and incidents of tumors didn't follow simple dose-response patterns, nor was there a linear association with duration or frequency of use.
For example, "Compared with never users, current marijuana users had a nonsignificant increase in risk (OR, 1.38; 95% CI, 0.67-2.87), whereas former users had greater than 2-fold risk (OR, 2.28; 95% CI, 1.17-4.43)."
And "compared with never users, those who reported using marijuana less often than once per week were more than twice as likely to develop TGCT (OR, 2.10; 95% CI, 1.09-4.03), whereas those who reported more frequent use had a lesser and nonsignificant increase in risk (OR, 1.53; 95% CI, 0.73-3.24). Men who reported <10 years of marijuana use were more than twice as likely to develop TGCT (OR, 2.09; 95% CI, 1.09-3.98), whereas a lesser and nonsignificant increase was observed for those reporting ≥10 years of use (OR, 1.51; 95% CI, 0.66-3.47) "